sars-cov mpro-in-1 — TargetMol Chemicals

Cat No.	Product Name	Targets
T37174	SARS-CoV MPro-IN-1
	MProinhibitor 11b is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.04 μM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-in...
T60686	SARS-CoV-2 Mpro-IN-1
	SARS-CoV-2 Mpro-IN-1 (compound 16b-3) is a potent, selective and irreversible SARS-CoV-2 main protease (Mpro) inhibitor (IC 50 = 116 nM) [1].
T72230	SARS-CoV-2/MERS Mpro-IN-1
	SARS-CoV-2/MERS Mpro-IN-1 is a potent inhibitor of the main proteases in SARS-CoV-2 and MERS, exhibiting IC50 values of 0.10 and 0.06 µM, respectively.
T37173	MPro Inhibitor 11a
	MProinhibitor 11a is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.053 μM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-i...
T12836	SARS-CoV-2-IN-1	Others
	SARS-CoV-2-IN-1 is a potent inhibitor of Mpro(SARS-CoV-2 Mpro, SARS-CoV Mpro and MERS-CoV Mpro with IC50s of 0.67, 0.90 and 0.58 μM, respectively).	Others
T81210	SARS-CoV-2 Mpro-IN-12	SARS-CoV
	SARS-CoV-2 Mpro-IN-12 (compound D026) serves as an inhibitor of the main protease (Mpro) of SARS-CoV-2, exhibiting antiviral properties [1].	SARS-CoV
T79279	SARS-CoV-2 Mpro-IN-8	SARS-CoV
	SARS-CoV-2 Mpro-IN-8 (compound 6b) is an antiviral agent effective against SARS-CoV-2 [1].	SARS-CoV
T79515	SARS-CoV-2 Mpro-IN-10	SARS-CoV
	SARS-CoV-2 Mpro-IN-10 (27h) is a potent inhibitor of the Mpro enzyme, exhibiting IC50 and EC50 values of 10.9 nM and 43.6 nM, respectively. It is utilized in research focused on the SARS-CoV-2 virus [1].	SARS-CoV
T79278	SARS-CoV-2 Mpro-IN-7	SARS-CoV
	SARS-CoV-2 Mpro-IN-7 (compound 6g) effectively inhibits SARS-CoV-2 main protease (Mpro) with an IC50 value of 8.8 μM and exhibits a cytotoxic concentration (CC50) of 10 μM [1].	SARS-CoV
T38174	Mpro inhibitor N3 hemihydrate
	Mpro inhibitor N3 hemihydrate is a potent antagonist of the SARS-CoV-2 main protease (Mpro), demonstrating an EC50 of 16.77 μM against SARS-CoV-2. It exhibits specific inhibition of Mpro in a range of coronaviruses, incl...
T78895	TKB245	SARS-CoV
	TKB245 is a potent inhibitor of the SARS-CoV-2 main protease (Mpro), effectively inhibiting viral replication in VeroE6 cells [1].	SARS-CoV
T80636	SARS-CoV-2-IN-59	SARS-CoV
	SARS-CoV-2-IN-59 (compound E07), an imidazoline derivative, is a non-peptide small molecule that inhibits SARS-CoV-2 by targeting its main protease (Mpro). It exhibits robust binding with Mpro residues (Met 165, Gln 166,...	SARS-CoV
T81203	SARS-CoV-2-IN-68	SARS-CoV
	SARS-CoV-2-IN-68 (compound 6C) is a covalent inhibitor of both SARS-CoV-2 PLpro and Mpro, exhibiting potent antiviral properties by targeting the Zn-finger domain of PLpro [1].	SARS-CoV
T73900	(±)-Alliin
	(±)-Alliin, the principal active component in garlic, functions as a potential inhibitor of SARS-CoV-2's main protease (Mpro) [1].
T79455	SARS-CoV-2 Mpro-IN-9	SARS-CoV
	SARS-CoV-2 Mpro-IN-9 (compound c7), a nonpeptidic, noncovalent inhibitor of SARS-CoV-2 main protease (Mpro), exhibits potent inhibitory action (IC50 = 0.085 μM) and improved physicochemical and drug metabolism and pharma...	SARS-CoV
T79228	SARS-CoV-2-IN-50	SARS-CoV
	SARS-CoV-2-IN-50 (Compound X77C) is a potent inhibitor of the SARS-CoV-2 main protease (M^pro), exhibiting high affinity for the enzyme's catalytic site [1].	SARS-CoV
T79677	SARS-CoV-2-IN-58	Virus Protease
	SARS-CoV-2-IN-58 (Compound 21H) serves as an antiviral agent targeting SARS-CoV-2, demonstrating efficacy with an EC50 of 18 μM. It specifically inhibits the SARS-CoV-2 main protease (Mpro) with an IC50 value of 0.35 μM ...	Virus Protease
T62991	Mpro/PLpro-IN-1
	Mpro/PLpro-IN-1 (Compound 29) is a dual-acting inhibitor of SARS-CoV-2 protease.Mpro/PLpro-IN-1 is also a potent inhibitor of Mpro/PLpro, with micromolar inhibition of M pro (IC50:1.72 μM) and submicromolar inhibition of...
T79947	10-Hydroxyaloin A	SARS-CoV
	Hydroxyaloin A (10-10-Hydroxyaloin A) is a potent inhibitor of SARS-CoV-2, demonstrating significant efficacy in binding to the active site of the SARS-CoV-2 main protease (M^pro) [1].	SARS-CoV
T63735	SP inhibitor 1
	SP inhibitor 1 is an inhibitor of SARS-CoV-2 replication at non-toxic concentrations (0.3250<5.98 μM) in vitro. SP inhibitor 1 is a selective inhibitor of SARS-CoV-2 stinger protein (SP), acting on SP protein (IC50: 3.26...